Conversely, some people may get relatively high levels with the transdermal route or with injections. Differences in molecular weight between these esters are minor (Table) and can be ignored for simplicity. B Based on sublingual estradiol having ~2- to 5-fold greater bioavailability than oral estradiol per studies (Wiki; Sam, 2021). Oral estradiol 1.5 mg is equivalent to about 2 mg oral estradiol valerate (Wiki). Transfeminine people often ask about equivalent dosages of estradiol by different routes of administration. Low thyroid hormone may reduce circulation and oxygen delivery. Blood tests to measure hormone circulating in the blood must be correlated with symptoms. Some patients have normal TSH but low levels of T3 or low levels of free T4. Lastly, estrogen is essential for joint health, reducing inflammation, and promoting collagen synthesis, preventing injuries. It also supports cardiovascular health by modulating HDL/LDL cholesterol and nitric oxide production, essential for arterial elasticity and blood pressure regulation. At 417 Integrative Medicine, patients receive personalized care focused on the root cause of changes in thyroid. Tracking patterns helps identify subtle dysfunction before severe thyroid disease develops. If thyroid is producing too much hormone, headaches may accompany anxiety and palpitations. Or, when there is a hormone shortage, which has happened before and you can read about why those can happen in a previous post. For example, someone might be using an estradiol patch and is happy with it, but is getting a rash from the adhesive and wants to switch to a topical gel. The conversion factors provided are derived from current literature and applied as published; therefore, we cannot take responsibility for the accuracy or validity of these conversion factors.We are happy to expand the list of parameters. Table of conversion factors for Estradiol (E2) unit conversion to pmol/L, pg/mL, pg/dL, pg/100mL, pg%, pg/L, ng/L . For many people, that conversion works fine. Your body has to convert it to T3 before it can do anything useful. Most thyroid prescriptions are T4-only — Synthroid, levothyroxine. We track this alongside blood work to get the full picture. Optimal injection intervals vary depending on the ester and doses should be scaled by injection interval to match the listed total dose per week (Aly, 2021). Injection, total dose per week of an estradiol ester like estradiol valerate, estradiol cypionate, estradiol enanthate, or estradiol benzoate. For example, KEEPS randomized women to 0.45 mg of Premarin, a 50 mcg estradiol patch, or placebo, and the outcomes for hot flashes, night sweats, irritability, and insomnia were essentially the same, so I feel comfortable considering these doses to be equivalent. A thyroid test and detailed thyroid function test panel may help identify hidden imbalances contributing to persistent symptoms. If there is little thyroid hormone, chronic tension may occur. Both extremes disrupt hormone levels in the body. Much thyroid hormone can increase sensitivity to stress. Today, free T4 measures direct levels more accurately. Free T4 index was used historically to estimate active hormone. T3 testing and evaluation of free T3 are important when symptoms persist. Free T4 and Free T3 measure only the unbound hormone. That is why reviewing reference range values and clinical symptoms is essential.
