Symptoms for hypogonadal syndrome such as infertility, impaired libido, fatigue, and risk of depression have a great impact on the quality of life (QoL) 7,8. The prevalence of functional hypogonadism range is estimated from 12% for 50 year-old, to 30% for 70-year-old men , and the chance increased with obesity and aging . In addition to reduce mortality in cardiovascular patients, almost to the half. On the other hand, 28 patients (15.2%) died in C-group and all deaths (100%) were found to cardiovascular causes. Alternatively, the C-group exhibited an increase in their serum creatinine (1.16 ± 0.31 to 1.19 ± 0.58 mg/dL), an increase in uric acid (5.54 ± 1.2 to 5.44 ± 1.7 mg/dL), and a decrease in GFR (92.0 ± 20.1 to 87.0 ± 26.1 mL/min/1.73 m2). The treatment group (T-group) consisted of 312 patients and obtained TU 1000 mg for 12 weeks followed by 6-week intervals and for up to 8 years. Testosterone therapy (TTh) is the main treatment for elderly men with hypogonadism. The kidneys are vital organs that filter waste from the blood, balance fluids and electrolytes, and help manage blood pressure. It should never be given just to increase hormone levels without symptoms. If testosterone is used, transplant patients should be watched very closely. Testosterone and kidney function are two important parts of overall health, and research shows they are closely connected. Testosterone therapy may help some men with kidney disease, but it must be used with caution. Men who receive a kidney transplant sometimes continue to have low testosterone levels even after transplant. Regular lab tests must be done to monitor hormone levels, red blood cell counts, and kidney-related values like blood urea nitrogen (BUN) and creatinine. For men with kidney disease, however, using testosterone requires extra care. In these cases, testosterone replacement therapy (TRT) may be beneficial. Even if you’re living the healthiest lifestyle possible, for a very small percentage of men, their levels will still drop into a range that causes symptoms. The decision to start testosterone replacement therapy (TRT) will depend on the outcome of your assessment with your doctor. The hypothalamus instructs the pituitary gland to release luteinising hormone (LH) which prompts the Leydig cells in the testes to produce testosterone. It depends on what your healthcare provider suspects is causing erectile dysfunction. Specifically, kidney function declines faster in men than in women, and the mortality rate is higher in men at all levels of pre-dialysis CKD . Renal replacement therapy (dialysis or kidney transplantation), which is the treatment to enable survival during end-stage renal disease, has become the leading cost in health care systems in developed countries . Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. With our at-home finger-prick blood test, check your levels — including the biologically active form of testosterone — for a clearer picture of your hormone health As research in this field advances, the potential clinical applications and therapeutic interventions may hold promise for individuals at risk of kidney disease or those seeking to optimize their overall health.