According to Panay and Fenton , young women’s ovaries produce approximately three to four times more testosterone than estrogen daily. It therefore stands to reason that an imbalance in androgen biosynthesis or metabolism in women may have undesirable effects on any or all of these domains. A double-blind randomized trial demonstrated that androgens affect sexual desire, bone density, muscle mass and strength, adipose tissue distribution, mood, energy, and psychological well-being . Notwithstanding this, controversy exists concerning the existence of androgen-deficiency states and their clinical diagnosis and management. In England and Australia, testosterone has been licensed for use in women for more than 60 years. Nonetheless, despite conflicting results, these hormones may influence arrhythmia occurrence both in the presence or absence of underlying structural heart disease. However, the link between the sex hormones and susceptibility to arrhythmias is still a matter of debate. A study on hormone replacement for 1 year confirmed that the use of ERT increases the QTc interval (73). Concerning hormone replacement in females, there are several studies in post-menopausal women showing that estrogen replacement therapy (ERT) prolongs the QTc interval. This has led to multiple pharmacovigilance studies assessing the link between hormone replacement therapy (HRT) and the incidence of ventricular arrhythmias. To understand the connection between TRT and heart rate, researchers have looked at various types of studies. TRT can possibly increase heart rate by affecting the nervous system, boosting metabolism, or changing how active a person feels. This helps to find out if the therapy is affecting the heart and if any changes in heart rate are happening. Perhaps it is time for the FDA to consider approving products that would benefit testosterone-deficient women. The safety of testosterone use in women has been evaluated for the past 80 years. This has resulted in millions of women suffering in silence with very common symptoms of perimenopause and menopause that could easily be addressed with the use of testosterone. Testosterone increases the production of red blood cells. Starting TRT without a valid diagnosis may lead to health risks and is not recommended. It is only approved for people with clear medical reasons for low testosterone. Doctors usually select the form that offers steady hormone levels and is easy for the patient to use safely. It plays a key role in many body functions, including muscle growth, bone health, mood, and sex drive. A fast heart rate may be a normal response in some cases or a sign of a problem in others. Oral testosterone can still lead to hormone level fluctuations. Some older versions of oral testosterone were linked to liver problems, but newer forms are designed to reduce that risk. There is also the risk of accidentally transferring testosterone to others through skin contact. The amount of testosterone absorbed can vary between people. Because the hormone is absorbed slowly through the skin, the nervous system and cardiovascular system are less likely to be overstimulated.
